DEAR COLLEAGUES... This is a comprehensive advanced symposium for bone scientists, bone interestees, and clinicians of orthopedic, oral and maxillofacial, craniofacial, and neurosurgery patterned after the Portland Bone Symposium of years past. This symposium will bring together today’s’ leading researchers and clinicians such as A. Hari Reddi, John E. Davies, Philippe Hernigou, H. Thomas Temple, Julie Glowacki, Jeffrey O. Hollinger, Cameron M. L. Clokie and others to share their data and techniques. Current topics concerning both the research and clinical application for the BMP’s, stem cells, cytokines, tissue engineering, reconstructive approaches, osteoporosis, bisphosphonate toxicity and more will be presented. We will also feature an evening dinner amidst a prehistoric setting featuring a lecture by the World Renown Paleontologist Jack Horner titled "What the Bones of Tyrannosaurus Rex Tell Us." The objectives and purposes of this symposium are simply the sharing and updating of knowledge related to bone science and the gathering of those interested to bring about collaborative efforts and foster further studies. Upon completion of this conference participants will be able to: •  have a comprehensive understanding of modern bone biology, tissue engineering, gene therapy, and bone regenerative mechanisms; •  understand stem cell biology and its applications to clinical practice; •  recognize the clinical utilization of recombinant bone morphogenetic protein and its limitations; •  identify the disease of osteoporosis, its treatment alternatives and the complications; that can result from therapy. This symposium is dedicated to Jeffrey O. Hollinger, originator of the Portland Bone Symposium and current Director of the Bone Tissue Engineering Center at the Carnegie Mellon Institute of Bone Science. It will also honor Dr. Phillip J. Boyne for his life long contributions to bone science and BMP research. Please join us for a profoundly educational and fun 21/2 days. We look forward to seeing you in Orlando! Robert E. Marx, DDS Professor and Chief Division of Oral & Maxillofacial Surgery Miller School of Medicine University of Miami Cameron M. L. Clokie, MD, PhD Professor & Head Oral & Maxillofacial Surgery Department of Clinical Science University of Toronto MIAMI - TORONTO BONE SYMPOSIUM

SYMPOSIUM SPEAKERS MIAMI - TORONTO BONE SYMPOSIUM

SYMPOSIUM SCHEDULE MIAMI - TORONTO BONE SYMPOSIUM

HOTEL INFORMATION Rising majestically between the shores of Bay Lake and Seven Seas Lagoon, Disney’s Contemporary Resort immerses you in a world of modern art and landmark architecture as sleek monorails silently glide through the center of the stunning atrium lobby. You’ll enjoy the distinctive style of oversized guest rooms and suites, most with dramatic lakefront or Theme Park views, along with a marina, health club, tennis center and an expansive pool area. For a truly memorable dining experience, the award-winning California Grill offers breathtaking views of Cinderella’s Castle from high atop the hotel. And, you’re just a short stroll or monorail ride away from all the sights and sounds of the Magic Kingdom Park® and Epcot®. During your stay, enjoy the convenience of Disney transportation throughout the Walt Disney World® Resort. Just steps from your door, boats and motor coaches are waiting to take you to and from the Theme Parks, Water Parks, the Downtown Disney®, and more. The hotel is offering special rates during this conference of $195.00 single or double plus tax, European plan (no meals). The cut off date to make reservations is September 30, 2008 after this date reservations are subject to hotel availability. Subject to availability of group rate rooms, you may reserve rooms at your group room rates for three days before October 30, 2008 and three days after November 1, 2008. CALL group reservations NOW at 407/824.3869 and identify yourself as attending the MTBS or Bone Symposium! ADDITIONAL INFORMATION As a Disney Resort Guest, you will enjoy special benefits that make your Walt Disney World® stay easier and more relaxing than ever. These benefits provide everything from extra time in the Theme Parks and convenient transportation for more magic all around. For advance purchase of specially priced Disney Meeting/Convention Theme Park tickets,go to www.disneyconventionear.com/MECCI DISNEY’S MAGICAL EXPRESS SERVICE If you are arriving by air, Disney’s legendary service starts the moment you touch down. There is no need to hassle with your luggage at baggage claim. Disney’s Magical Express Service is complimentary and exclusively available when you stay at a Disney Resort hotel. Disney will pick you up at Orlando International Airport and retrieve your checked luggage, then take you to your Disney Resort hotel. When your meeting is over, they will do it all in reverse. In order to utilize this service, a Disney’s Magical Express reservation is required and must be arranged prior to arrival at the airport. To book Disney’s Magical Express Service, call 407.827.6777 or visit www.disneymeetings.com/magicalexpress for more details. For more information on Walt Disney World® go to www.disneyconventionears.com MIAMI - TORONTO BONE SYMPOSIUM

CME CREDIT / REGISTRATION INFORMATION   ACCREDITATION The Medical Educator Consortium, is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. CREDIT HOURS The Medical Educator Consortium, designates this educational activity for a maximum of 14.5 credit hours for the general session, 1.5 credit hours for the Keynote Dinner in category 1 towards the AMA Physician’s Recognition award. FACULTY AND DISCLOSURE INFORMATION In accordance with accreditation requirements, will disclosure any significant financial interest or other relationship with the manufacturer(s) of any commercial product(s) and/or provider(s) of commercial services discussed in an educational presentation and with any commercial supporters of the activity. REGISTRATION INFORMATION $750 for Physicians/Oral & Maxillofacial Surgeons/Research Scientist $600 for Residents/Fellows/Military (with letter from Chief) $125 for Evening Dinner & Keynote Lecture by World Renowned Paleontologist, Mr. Jack Horner Registration fee includes admission to the symposium, exhibit areas and handout material. Continental breakfast will be provided at the beginning of each morning session. Refreshments will also be provided during the sessions. Each participant must provide his or her own lunch and dinner. Refunds will be made only if written notice of cancellation is received prior to September 30, 2008. After September 30, 2008 no refunds will be issued. A $150 fee is charged on all refunds.     For Additional Information and Special Assistance Contact MECC (Meetings Events & Conference Coordinators, Inc.) 1550 S. Dixie Hwy, Ste 202, Coral Gables, FL 33146 Telephone 305/663-1628 Office Fax 305/675-2718 Or visit our website at www.meccinc.com MIAMI - TORONTO BONE SYMPOSIUM

REGISTRATION FORM MIAMI–TORONTO BONE SYMPOSIUM OCTOBER 31 - NOVEMBER 2, 2008 MIAMI - TORONTO BONE SYMPOSIUM